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Properties of substance:

furosemide

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C12H11ClN2O5S

Molar/atomic mass: 330.75

Melting point (°C):

206

CAS №: 54-31-9

Solubility (g/100 g of solvent):

acetone: soluble [Ref.]
chloroform: sparingly soluble [Ref.]
dimethylformamide: soluble [Ref.]
ethanol: sparingly soluble [Ref.]
methanol: soluble [Ref.]
water: 0.00731 (30°C) [Ref.]

Dissociation:

pKa (1) = 3.9 (25°C, water)

LD50 (mg/kg):

2600 (rats, oral)
800 (rats, intravenous)
2000 (mice, oral)
308 (mice, intravenous)
2000 (dogs, oral)

References:

  1. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 944-945
  2. The Merck Index 11th ed., Merck & Company, 1989. - pp. 674
  3. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 834
  4. Регистр лекарственных средств России: Энциклопедия лекарств. - 11 изд. - М.: ООО РЛС-2004, 2004. - pp. 951-952 [Russian]
  5. Токсикологическая химия. - Под ред. Плетеневой Т.В. - М.: ГЭОТАР-Медиа, 2005. - pp. 66 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru