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Properties of substance:

N-(4-ethoxyphenyl)acetamide

Synonyms:

phenacetin

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C10H13NO2

Structural formula as text:

C2H5OC6H4NHCOCH3

Molar/atomic mass: 179.22

Melting point (°C):

135

Solubility (g/100 g of solvent):

acetic acid 99,5%: 15.81 (21.5°C) [Ref.]
acetone: 11.96 (30°C) [Ref.]
amyl acetate: 2.48 (30°C) [Ref.]
amyl alcohol: 3.64 (25°C) [Ref.]
aniline: 10.45 (30°C) [Ref.]
benzaldehyde: 9.22 (30°C) [Ref.]
benzene: 0.65 (30°C) [Ref.]
carbon tetrachloride: 0.037 (25°C) [Ref.]
chloroform: 5 (25°C) [Ref.]
diethyl ether: 1.58 (25°C) [Ref.]
ethanol 90%: 8.48 (25°C) [Ref.]
ethanol abs.: 7.11 (25°C) [Ref.]
glycerol 99.04%: 0.47 (20°C) [Ref.]
petroleum ether: 0.02 (20°C) [Ref.]
pyridine: 17.39 (20°C) [Ref.]
pyridine 50% aq.: 28.94 (20°C) [Ref.]
quinoline: 7.83 (20°C) [Ref.]
toluene: 0.3 (25°C) [Ref.]
water: 0.03603 (15°C) [Ref.]
water: 0.0502 (25°C) [Ref.]
water: 1.186 (100°C) [Ref.]
xylene: 1.27 (32.5°C) [Ref.]

LD50 (mg/kg):

3600 (rats, oral)
866 (mice, oral)

References:

  1. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1606
  2. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 670-671
  3. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 674
  4. Альберт А. Избирательная токсичность. - Т.1. - М.: Медицина, 1989. - pp. 118 [Russian]
  5. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 183 [Russian]
  6. Краткая химическая энциклопедия. - Т. 5: Т-Я. - М.: Советская энциклопедия, 1967. - pp. 385 [Russian]
  7. Неотложная помощь при острых отравлениях: Справочник по токсикологии. - Под ред. Голикова С.Н. - М.: Медицина, 1977. - pp. 146 [Russian]
  8. Справочник по растворимости. - Т.1, Кн.2. - М.-Л.: ИАН СССР, 1962. - pp. 1233, 1536 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru