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Properties of substance:

methylene blue trihydrate



skc-file

Group of substances:

organic

Physical appearance:

deep-green crystals

Empirical formula (Hill's system for organic substances):

C16H24ClN3O3S

Molar/atomic mass: 373.898

Melting point (°C):

190

Decomposition temperature (°C):

190

Solubility (g/100 g of solvent):

benzene: insoluble [Ref.]
chloroform: practically insoluble [Ref.]
diethyl ether: practically insoluble [Ref.]
ethanol: 1.3 (20°C) [Ref.]
water: 4.36 (20°C) [Ref.]

LD50 (mg/kg):

1180 (rats, oral)
1250 (rats, intravenous)
180 (rats, intraperitoneal)
3500 (mice, oral)
77 (mice, intravenous)
150 (mice, intraperitoneal)

References:

  1. Dean J.A. Lange's handbook of chemistry. - 1999. - pp. 1.266-1.267
  2. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1303-1304
  3. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 11ed. - Wiley-interscience, 2004. - pp. 484-485
  4. Sabnis R.W. Handbook of Biological Dyes and Stains. - Wiley, 2010. - pp. 296-297
  5. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 328 [Russian]
  6. Краткая химическая энциклопедия. - Т. 3: Мальтаза-Пиролиз. - М.: Советская энциклопедия, 1964. - pp. 184 [Russian]
  7. Справочник по растворимости. - Т.1, Кн.1. - М.-Л.: ИАН СССР, 1961. - pp. 75 [Russian]
  8. Халецкий А.М. Фармацевтическая химия. - Л.: Медицина, 1966. - pp. 299-300 [Russian]
  9. Химическая энциклопедия. - Т. 3. - М.: Советская энциклопедия, 1992. - pp. 61 [Russian]
  10. Химический энциклопедический словарь. - Под ред. Кнунянц И.Л. - М.: Советская энциклопедия, 1983. - pp. 331-332 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru