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Properties of substance:

physostigmine



skc-file

Group of substances:

organic

Physical appearance:

colorless crystals

Empirical formula (Hill's system for organic substances):

C15H21N3O2

Molar/atomic mass: 275.346

Melting point (°C):

107

CAS №: 57-47-6

Solubility (g/100 g of solvent):

benzene: soluble [Ref.]
chloroform: very soluble [Ref.]
diethyl ether: very soluble [Ref.]
ethanol: very soluble [Ref.]
methylene chloride: soluble [Ref.]
water: slightly soluble [Ref.]

Dissociation:

pKBH+ (1) = 6.12 (25°C, water)
pKBH+ (1) = 12.24 (25°C, water)

LD50 (mg/kg):

0.8 (rabbits, intravenous)
3 (rabbits, subcutaneous)
0.75 (mice, subcutaneous)

References:

  1. Buckingham J. B., Baggaley K. H., Roberts A. D., Szabo L. F. Dictionary of Alkaloids. - 2 ed. - CRC Press, 2010. - pp. 1521
  2. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 900-901
  3. Gangolli S. The Dictionary of Substances and their Effects. - 2 ed., Vol. 6, O-S. - RSC, 1999. - pp. 360-361
  4. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 381 [Russian]
  5. Военная токсикология, радиобиология и медицинская защита. - Под ред. Куценко С.А. - СПб.: Фолиант, 2004. - pp. 278 [Russian]
  6. Химическая энциклопедия. - Т. 5. - М.: Советская энциклопедия, 1999. - pp. 94-95 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru