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Properties of substance:

minoxidil



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C9H15N5O

Molar/atomic mass: 209.2483

Melting point (°C):

248

Solubility (g/100 g of solvent):

1-butanol: 1.11 (5°C) [Ref.]
1-butanol: 1.6 (20°C) [Ref.]
1-butanol: 1.84 (25°C) [Ref.]
1-butanol: 4.04 (60°C) [Ref.]
1-propanol: 1.51 (5°C) [Ref.]
1-propanol: 2.1 (20°C) [Ref.]
1-propanol: 2.44 (25°C) [Ref.]
1-propanol: 5.3 (60°C) [Ref.]
2-propanol: 0.77 (5°C) [Ref.]
2-propanol: 0.9 (10°C) [Ref.]
2-propanol: 1.2 (20°C) [Ref.]
2-propanol: 1.37 (25°C) [Ref.]
2-propanol: 3.16 (60°C) [Ref.]
acetone: insoluble [Ref.]
acetonitrile: insoluble [Ref.]
benzene: insoluble [Ref.]
benzylic alcohol: 12 [Ref.]
chloroform: 0.034 [Ref.]
diethyl ether: insoluble [Ref.]
dimethylsulfoxide: 0.59 [Ref.]
ethanol abs.: 1.78 (5°C) [Ref.]
ethanol abs.: 2.48 (20°C) [Ref.]
ethanol abs.: 2.76 (25°C) [Ref.]
ethanol abs.: 3.1 (30°C) [Ref.]
ethanol abs.: 6.08 (60°C) [Ref.]
ethyl acetate: insoluble [Ref.]
glycerol: 3.7 [Ref.]
methanol: 4.88 (5°C) [Ref.]
methanol: 5.73 (15°C) [Ref.]
methanol: 6.22 (20°C) [Ref.]
methanol: 6.8 (25°C) [Ref.]
methanol: 9.14 (40°C) [Ref.]
methanol: 11.16 (50°C) [Ref.]
methanol: 13.67 (60°C) [Ref.]
propylene glycol: 7.2 [Ref.]
water: 0.18 (5°C) [Ref.]
water: 0.24 (20°C) [Ref.]
water: 0.27 (25°C) [Ref.]
water: 0.63 (60°C) [Ref.]

References:

  1. Analytical Profiles of Drug Substances. - Vol. 17, Edited by K. Florey. - Academic Press, 1988. - pp. 187-219
  2. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 786-787
  3. Drugs. - 1981. - Vol. 22, No. 4. - pp. 257-278 [DOI: 10.2165/00003495-198122040-00001]
  4. Elks J., Ganellin C.R. Dictionary of Drugs: Chemical Data, Structures and Bibliographies. - Springer, 1990. - pp. 827
  5. Journal of Chemical and Engineering Data. - 2011. - Vol. 56, No. 5. - pp. 2720-2722 [DOI: 10.1021/je1012839]
  6. Journal of Organic Chemistry. - 1975. - Vol. 40, No. 22. - pp. 3304-3306 [DOI: 10.1021/jo00910a040]
  7. The Merck Index 11th ed., Merck & Company, 1989. - pp. 976-977
  8. Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 426-427 [Russian]
  9. Патент Европы EP1,073,439 (от 28.10.1999)

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru